Nota 1697708239

Protein misfolding diseases, such as cardiac amyloidosis, are a group of devastating and often progressive conditions characterized by the abnormal folding of specific proteins in the body. This misfolding can lead to the accumulation of protein deposits in various organs, disrupting their normal function and causing a wide range of symptoms. Cardiac amyloidosis is a particularly concerning subtype of protein misfolding disease that primarily affects the heart. In this condition, abnormal proteins, typically amyloid fibrils composed of misfolded proteins, build up in the heart tissue. The most common proteins involved in cardiac amyloidosis are immunoglobulin light chains (AL amyloidosis) or transthyretin (ATTR amyloidosis). updated