Light chain amyloidosis

In this chapter we can see some insights about systemic light chain (AL) amyloidosis with focus on the main clinical characteristics and on the pathway to correct diagnosis. The disease is rapidly progressive, and it is still diagnosed late, since most of the symptoms and clinical manifestations are nonspecific. Heart is one of the major organs affected, so cardiologists play an important role in early recognition of the disease. The diagnosis of AL amyloidosis needs to be biopsy proven. Identify the type of amyloid fibril is critical to avoid misdiagnosis and beginning of inappropriate treatment.